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Year : 2022  |  Volume : 45  |  Issue : 1  |  Page : 2-15

Medical management of ionizing radiation-induced skin injury

1 CBRN Protection and Decontamination Research Group, Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
2 Department of Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India
3 Department of Textile and Fibre Engineering, Indian Institute of Technology, Delhi, India
4 Department of Chemistry, Miranda House, University of Delhi, Delhi, India
5 Vice Chancellor, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India
6 Department of Chemistry, Shivaji College, University of Delhi, Delhi, India

Correspondence Address:
Rajeev Goel
CBRN Protection and Decontamination Research Group, Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Delhi - 110 054
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/rpe.rpe_4_21

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Skin radiation exposure occurs during planned or unplanned radiation events, such as radiotherapy or nuclear radiation accidents, respectively, resulting into acute and chronic effects depending upon the extent of the radiation exposure or contamination. Radioactive nuclide-induced contaminations severely affect the human skin as skin is the largest organ of the body. Skin radioactive contamination may result into radiation-induced burns that may significantly cause morbidity without any medical intervention. In such scenario, it is necessary to provide priority to severe and life-threatening injuries. The current review provides a holistic picture about the mode of occurrence of radiation injuries, types of radiation burns, local skin effects and pathophysiology, prognosis, diagnosis and treatment, and challenges in the management of radiation wounds. Further, the review also includes the dressings used for irradiated wounds and comparison of amniotic and silver dressings, which possess potential bactericidal and wound-healing properties.

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